Dendritic cell-based vaccine: a promising approach for cancer immunotherapy
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چکیده
منابع مشابه
Dendritic cell-based immunotherapy: A promising approach for treatment of cancer Review Article
Dendritic cells (DC) are the most potent antigens presenting cells with the capacity to stimulate naive T cells and induce primary and secondary immune responses. Due to these features DC have been exploited for vaccine delivery in an attempt to actively immunize cancer patients, but the vaccineinduced immune responses have achieved partial success but are not yet sufficient to attain robust an...
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The accumulating evidence in favor of tumor immunosurveillance indicates that immunotherapies may prove effective for the treatment of cancer. Many current approaches against cancer immunotherapy are often limited in their potential to induce effective anti-tumor immune responses. However, recent approach with dendritic cell based therapy proves to be an effective method for induction of anti-t...
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Cancer immunotherapy has gained a lot of interest over the past few years due to the success of immune checkpoint inhibitors in treating cancer (1, 2). Immune checkpoint inhibitors, such as monoclonal antibodies against cytotoxic T-lymphocyte–associated antigen 4 (CTLA-4) and programmed death 1 (PD-1), have been shown to increase survival of patients with advanced cancers (1, 2). These in...
متن کاملDendritic Cell Immunotherapy, the Next Step in Cancer Treatment
Cancer immunotherapy has gained a lot of interest over the past few years due to the success of immune checkpoint inhibitors in treating cancer (1, 2). Immune checkpoint inhibitors, such as monoclonal antibodies against cytotoxic T-lymphocyte–associated antigen 4 (CTLA-4) and programmed death 1 (PD-1), have been shown to increase survival of patients with advanced cancers (1, 2). These in...
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Background: Bacterial DNA has immunostimulatory effects on different types of immune cells such as dendritic cells (DCs). Application of DCs as a cellular adjuvant represents a promising approach in the immunotherapy of infectious disease and cancers. Objectives: To investigate the effect of tumor antigen pulsed DCs in the presence of CpG-1826 in treatment of a murine model of cancer. Methods: ...
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ژورنال
عنوان ژورنال: Leukemia
سال: 1999
ISSN: 0887-6924,1476-5551
DOI: 10.1038/sj.leu.2401394